Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium
نویسندگان
چکیده
BACKGROUND In vitro studies have suggested the corneal cytotoxicity of third-generation fluoroquinolone levofloxacin (LVFX) and fourth-generation fluoroquinolone moxifloxacin hydrochloride (MFLX) among fluoroquinolone antibacterial eye drops. This study investigated the effects of these two eye drops on the human cornea in vivo. METHODS We evaluated 30 healthy adults (19 men and 11 women, 38.3 ± 6.3 years old). Each subject received an LVFX ophthalmic solution 0.5% in one eye and an MFLX ophthalmic solution 0.5% in the other eye three times daily for 7 days. Functional and morphological corneal changes before and after instillation were evaluated through ophthalmic examinations including breakup time of tear film (BUT) as measured by fluorescein staining and DR-1, Schirmer I test, Heidelberg Retina Tomograph II Rostock Cornea Module (HRTII-RCM), specular microscope, and Pentacum examination. RESULTS Both the LVFX and MFLX groups had no significant change in each examination before and after instillation. There was also no statistically significant difference in measurements after the 7-day instillation between the groups. CONCLUSION Our study results suggest that as with LVFX, MFLX used in a normal clinical setting is unlikely to cause any obvious adverse effects on human normal cornea.
منابع مشابه
Effect of topical fluoroquinolones on the expression of matrix metalloproteinases in the cornea
BACKGROUND Matrix metalloproteinases play an important role in extracellular matrix deposition and degradation. Based on previous clinical observations of corneal perforations during topical fluoroquinolone treatment, we decided to evaluate the comparative effects of various fluoroquinolone eye drops on the expression of matrix metalloproteinases (MMPs) in cornea. METHODS Eighty female Lewis ...
متن کاملEffect of corneal epithelium on ultraviolet-A and riboflavin absorption.
PURPOSE To determine if the corneal epithelium prevents the collagen cross-linking effect. Using immunofluorescence microscopy after CXL, we indirectly analyzed the role of the epithelium as ultraviolet-A (UVA) shield as well as a barrier to riboflavin penetration. METHODS Fifteen freshly enucleated porcine eyes were divided into 3 groups. The corneal epithelium was kept intact in all groups....
متن کاملRole of recipient epithelium in promoting survival of orthotopic corneal allografts in mice.
PURPOSE To determine whether epithelium-deprived corneal allografts covered with syngeneic epithelium display immune privilege in orthotopic transplantation and whether syngeneic epithelium containing antigen-presenting cells nullifies this effect. METHODS Epithelium-deprived allogeneic corneas (C57BL/6) and epithelium-deprived allogeneic corneas reconstituted with syngeneic (BALB/c) epitheli...
متن کاملRecent Developments Homeobox Genes and Vertebrate Eye Development
During eye development, tissues that begin as apparently homogeneous populations of cells become subdivided into specialized compartments. For example, the optic vesicle, which begins as an undifferentiated single layer of neuroepithelial cells, eventually forms all the cell types of the retina, the two layers of the ciliary epithelium, the retinal pigmented epithelium, the iris epithelia, and ...
متن کاملCorneal Endothelial Tissue Bioengineering Using Cultured Human Corneal Endothelial Precursor Cells
The cornea is composed of a multilayered epithelium, Bowman's membrane, stroma, Descemet's membrane, and endothelium. The corneal endothelium (CE) is a single layer of hexagonal cells that separates the corneal stroma from the aqueous humor of the anterior chamber. Transparency of the cornea is maintained by regulation of stromal hydration through the barrier and pump functions of the CE, and c...
متن کامل